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KMID : 0385220000100010046
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Korean Journal of Gerontology
2000 Volume.10 No. 1 p.46 ~ p.59
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Generation, toxicity and Scavenging of ONOO￣: Its Involvement in the Aging Process
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Chung Hae-Young
Soung Do-Yu
Choi Hye-Ry
Choi Jae-Sue
Yang Ryung
Yu Byung-Pal
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Abstract
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This review discusses a recent research progress made on ONOO￣. ONOO￣produced from a reaction of O₂￣ with iNOS (Inducible NO Synthase)-generated NO is a potent cytotoxicant that is capable of modification of various cellular constituents including oxidation of thiol groups, nitration of tyrosine, lipid peroxidation reaction and age-related signal transduction. Its deleterious actions are implicated in various age-related diseases such as Alzheimer’s disease, rheumatoid arthritis, cancer and atherosclerosis. The major protective problem against ONOO￣ is, in contrast to oxygen-derived reactive species, a lack of endogenous defense enzyme specific for its detoxification. In this review, discussion on the nature of endogenous as well as erogenous sources of defenses against ONOO￣ was highlighted.
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KEYWORD
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ONOO￣, Toxicity, Scavenging, Aging
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